| SO2污染对小鼠骨髓细胞微核的诱发作用 |
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| 作者姓名： | Meng Z Ruan A Sang N Zhang B Zhang J |
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| 作者单位： | 山西大学环境医学与毒理学研究所,山西大学生命科学系,太原,030006 |
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| 基金项目： | 国家自然科学基金资助项目 (30 0 70 6 4 7),山西省自然科学基金资助项目 |
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| 摘 要： | 在SO2吸入慢性染毒条件下,小鼠骨髓嗜多染红细胞（PCE）的微核细胞率与微核率均显著增加,且雌雄差异显著。结果也表明,SO2对阳性致突变剂乌拉坦航发微核的作用有显著抑制效应。本研究模拟SO2空气污染,从整体水平直接证实了SO2是哺乳类细胞染色体断裂剂、SO2与阳性致突变剂的联合作用是复杂的结论。
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| 关 键 词： | 诱发作用 SO2 微核 小鼠 骨髓细胞 乌拉坦 二氧化硫 大氧污染 |
| 文章编号： | 0250-3301(2002)04-03-0123 |
| 修稿时间： | 2001年7月3日 |
Micronuclei induced by chronic inhalation of SO2 in mouse bone marrow cells |
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| Meng Z,Ruan A,Sang N,Zhang B,Zhang J.Micronuclei induced by chronic inhalation of SO2 in mouse bone marrow cells[J].Chinese Journal of Environmental Science,2002,23(4):123-125. |
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| Authors: | Meng Ziqiang Ruan Aidong Sang Nan Zhang Bo Zhang Jianbiao |
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| Institution: | Institute of Environmental and Toxicology, Department of Life Sciences, Shanxi University, Taiyuan 030006. |
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| Abstract: | In the chronic inhalation experiment of sulfur dioxide(SO 2), micronuclei(MN) frequencies in the polychromatophilic erythroblasts(PCE) of mouse bone marrow and the frequencies of cells with MN were significantly increased in dose dependent manner. There was a singnificant difference between the male and the female animals. The results also showed that SO 2 inhibited urethone induced MN formation. These results furtherly confirm that SO 2 inhalation was a clastogenic and genotoxic agent to mammalian cells, and the combined effects of SO 2 and other mutagens are complex. |
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| Keywords: | SO 2 micronuclei mouse bone marrow cells urethone |
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