藻毒素复合污染对鱼体的免疫毒性研究

针对水体富营养化问题，通过单一暴露和联合暴露方式研究两种MCs四种暴露剂量（0．1，1，10，100μg／L）下对鱼体的免疫毒效应。结果发现，不同剂量MCLR和MCRR单一暴露都能使鲫鱼淋巴细胞发生死亡，呈现明显的剂量效应和时间效应关系。且MCLR对鱼体的毒性相对McRR要更显著；MCLR和McRR复合暴露对鱼体淋巴细胞的毒性效应表现为协同作用，且随着毒素浓度的增加，其毒性效应差异显著性也随之升高，故而鱼体的免疫系统造成重大的影响，因此应当加强控制藻毒素在水体中的复合污染。

STUDY ON THE IMMUNE TOXICITY OF COMBINED CYANOBACTERIUM TOXINS ON FISH

According to the problem of water eutrophication, through comparisoning the poison effect on fish by the different MCs, including 0.1μg/L,11μg/L,10μg/L and 100μg/L, discovered that after exposed 1μg/L MCLR, the mortality rate of Lymphocytes was closed to the MCRR test group; compared with the MCLR exposure group, the toxicity of the MCRR induc- tion group was relatively weak; MCLR and MCRR have synergistic effect on fish iymphocytes. Results show that MCLR and MCI~IR with 0.1μg/L microcystins single exposured can cause the lymphocytes death, and with the increasing toxin, it will have a dose-effect relationship clearly, therefore ,it may affect the fish＇s immune system; it will produce synergy on toxic fish if the microcystins MCLR and MCRR composite exposed. We should strengthenthe the control of the composite cyanobacterial toxins in the water pollution.