Cobalt induced changes in immune response and adenosine triphosphatase activities in rats |
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| Authors: | K N Chetty DSV Subba Rao L Drummond D Desaiah |
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| Institution: | 1. M. I. College , Holly Springs, Mississippi, 38635;2. Departments of Surgery , The University of Mississippi Medical Center , Jackson, Mississippi, 39216;3. Departments of Neurology , The University of Mississippi Medical Center , Jackson, Mississippi, 39216 |
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| Abstract: | Abstract The immuno‐biochemical effects of cobaltous chloride in rats receiving iron‐sufficient and deficient diets were investigated. Rats receiving 100 ppm or more cobalt showed a significant reduction in thymus and body weights along with a marked decrease in hemoglobin, hematocrit, sheep agglutinins and plaque forming cells. These effects were more pronounced in rats receiving cobalt mixed with iron‐deficient diet than those fed on iron‐sufficient diet. The Na+‐K+ and mitochondrial (Oligomycin‐sensitive) Mg2+ATPase activities in brain and liver of rats fed with iron‐deficient diets were decreased significantly. However, the ATPase activities in these tissues from rats fed with cobalt mixed with iron‐sufficient diets were not altered. |
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| Keywords: | Cobaltous chloride Iron Hemoglobin and Hematocrit values Plaque forming cells ATPase |
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