Oxidative stress and biochemical perturbations induced by insecticides mixture in rat testes |
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| Authors: | Fatma M El-Demerdash Ali B Jebur Hoda M Nasr |
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| Institution: | 1. Department of Environmental Studies, Institute of Graduate Studies and Research , Alexandria University , Alexandria , Egypt;2. Ministry of Education , Baghdad , Iraq;3. Department of Pest Control and Environmental Protection, Faculty of Agriculture , Damanhour University , Damanhour , Egypt |
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| Abstract: | The joint action of pyrethroids, lambda-cyhalothrin (LC) in combination with organophosphates, fenitrothione (FNT) on antioxidant defense system and lipid peroxidation biomarkers in rat testes was studied. The results suggest that incubation of testes homogenate with different concentrations of insecticide mixture for different time intervals significantly decreased the activity of antioxidant enzymes, like glutathione S-transferase (GST), superoxide dismutase (SOD) and catalase (CAT), and the level of reduced glutathione (GSH). In addition, a significant inhibition in transaminases (AST, ALT), phosphatases (AcP, AlP) activity and protein content were observed. On the other hand, FNT plus LC increased the cellular lipid peroxidation (LPO) level and the activity of lactate dehydrogenase (LDH). In conclusion, the use of insecticides mixture might cause marked oxidative damage in a concentration and time-dependent manner. |
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| Keywords: | Insecticides mixture cytotoxicity oxidative stress enzymes rat testes |
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