Introduction |
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| Authors: | August Curley A H El‐Sebae |
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| Institution: | 1. Chief, Toxic Effects Branch, Environmental Toxicology Division/HERL , U.S. Environmental Protection Agency , Research Triangle Park, NC, 27711;2. Associate Director, Science Centre for Postgraduate Studies , UNARC,Alexandria University , Alexandria, Egypt |
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| Abstract: | Abstract Eight pairs of O‐methyl and O‐ethyl O‐(substituted‐phenyl) phenylphosphonothionates were evaluated with respect to their delayed neurotoxic activity in hens. O‐methyl compounds were in all cases more active than their O‐ethyl analogs. The neurotoxic potential of the O‐methyl phenylphosphonothionates was 2,5‐diCl >4‐NO2 >2,4,5‐triCl and 2,4,6‐triCl >2,4‐diCl >2,5‐diCl‐4‐Br >4‐CN, when single oral doses were given. Both EPN‐ethyl and leptophos‐raethyl were more neurotoxic in multiple dermal than multiple oral dosing regimens. LD50s for mice and flies were established. |
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| Keywords: | organophosphorus ester induced delayed neurotoxicity |
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