赤潮甲藻毒素麻痹性贝毒的生物合成研究进展

简要介绍了赤潮甲藻毒素麻痹性贝毒的生物合成过程及毒素结构的化学转换和生物转换方面的研究进展。包括利用放射性标记物质喂养产毒甲藻Gonyaulax tamarensis的研究实验,提出了该甲藻是通过一个乙酸单元或者它的衍生物与精氨酸或其等价物在α碳上的胺基的克莱森聚合(CLAISEN),随后失去羰基碳,并在相邻的羰基碳上形成咪唑环而合成麻痹性贝毒的理论过程。还介绍了N-磺酰基耦联的麻痹性毒素被弱酸和生物系统中的N-磺酰酶水解时结构转换方面的研究进展。也介绍了我国的研究进展和该领域今后的研究方向。

Research progress on biosynthesis of phycotoxinsparalytic shellfish poisoning

This paper introduced research progress on biosynthesis of phycotoxins paralytic shellfish poisoning and its biochemical conversion. The biosynthesis of PSP has been studied using labeled precursors. The result can be given that the skeleton of the tncyclic ring system is formed by the Claisen-type condensation of acetate on the a-carbon of arginine with the loss of the carboxyl group of arginine and subsequent amidation and cyclization. Their N-sulfate groups are easily hydrolyzed by weak acid,and also possibly by N-sulfatase in the biological system. The progress and further sdudies in this area in China have been summarized as well.