Heredity and risk of disease |
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Authors: | Ranajit Chakraborty William J Schull Kenneth M Weiss |
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Institution: | Center for Demographic and Population Genetics, University of Texas, Health Science Center, Houston, Texas, U.S.A. |
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Abstract: | Mathematical modeling of competing risks often uses a single risk function for all individuals within a population. In this paper we use several specific examples to argue that such representations remain approximations until account is taken of the existence of genetic variability within and between populations, and the impact of this upon liability to disease. The extent of human genetic variability is also indicated. |
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