Abnormal karyotype in the chorion,not confirmed in a subsequently aborted fetus |
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| Authors: | Dr A Breed A Mantingh L Govaerts A Boogert G Anders R Laurini |
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| Institution: | 1. Department of Gynaecology and Obstetrics, University Hospital Groningen, The Netherlands;2. Department of Human Genetics, State University of Groningen, The Netherlands;3. Department of Pathology, State University of Groningen, The Netherlands |
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| Abstract: | An abnormal fetal karyotype, containing a del 16(q21-qter) as an extra chromosome, was diagnosed in all 14 metaphases examined in a sample of chorionic villous biopsy material. After elective abortion a mosaicism for this cell-line together with a normal one was detected in the chorionic tissue. Fibroblast cultures from several fetal skin biopsies all revealed a normal karyotype. |
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| Keywords: | Chorionic villous biopsy Chromosomal mosaicism False positive diagnosis |
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