Karyotypic differences between cells from placenta and other fetal tissues |
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| Authors: | Dr. M. Verjaal N. J. Leschot H. Wolf P. E. Treffers |
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| Affiliation: | 1. Institute of Human Genetics, University of Amsterdam, Academic Medical Centre. The Netherlands;2. Department of Obstetrics and Gynaecology, University of Amsterdam, Academic Medical Centre, The Netherlands |
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| Abstract: | Six cases are reported with discrepancies between the karyotypes of placental cells and cells from other fetal tissue. The respective findings were: (a) 48,+7,+18 resp. 47,+18. (b) 46, i(18q) resp. 46, del18(p11). (c) 46, XX resp. 46, XX/47, XXX. (d) 46, X, Yq+ and 46, XY resp. 46, XY. (e) 46/47,+12 resp. 46. (f) 46/47,+5 resp. 46. These differences were found in both early and term pregnancies. Care should be taken in deducing the fetal karyotype from the chromosomal pattern of placental cells. |
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| Keywords: | Prenatal diagnosis Placental karyotypes Karyotypic discrepancies Amniocentesis Chorionic villus biopsy |
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