Chorionic villi sampling changes maternal serum alpha-fetoprotein |
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| Authors: | Federico G. Mariona Rupi Bhatia Frank N. Syner Frederick Koppitch |
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| Affiliation: | 1. Division of Maternal-Fetal Medicine, Department of Obstetrics/Gynecology, Hutzel Hospital/Wayne State University School of Medicine, Detroit, Michigan, U.S.A.;2. Division of Maternal-Fetal Medicine, C.S. Mott Center for Human Growth & Development, Detroit, Michigan, U.S.A. |
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| Abstract: | Second trimester amniocentesis has traditionally been utilized for prenatal genetic diagnosis. Chorionic villi sampling (CVS) is presently offered as an alternative. The occurrence of fetomaternal bleed (FMB) during CVS could increase the rate of post sampling abortion and, additionally, be of significance in patients at risk for isoimmunization. Detection and quantitation of FMB can be accomplished by the determination of changes in maternal serum alpha-fetoprotein (MSAFP) before and after CVS. |
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| Keywords: | Chorionic villi sampling Alpha-fetoprotein Rh isoimmunization |
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