Prenatal diagnosis and fetal pathology of partial trisomy 20p–monosomy 4p resulting from paternal translocation |
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| Authors: | Dr E Vamos D Pratola N Van Regemorter M Freund J Flament-Durand F Rodesch |
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| Institution: | 1. Service d'Anatomie Pathologie. Hǒpital Universitaire Erasme, Belgium;2. Centre de Génétique Medicale & Bruxelles, U.L.B., Belgium;3. Centre de Génétique Médicale, Université Catholique de Louvain, Belgium;4. Service d'Obstétrique el Gynécologie, Hǒpital Universitaire Erasme Université Libre de Bruxelles, Bruxelles, Belgium |
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| Abstract: | Amniocentesis was performed in view of a paternal balanced chromosomal rearrangement t(4;20)(p16;p12), inv(18)(p11q11). The pregnancy was complicated by severe oligohydramnios. The fetal karyotype was unbalanced: 46XX, der(4), t(4;20)(p16;p12), inv(18) (p11q11)pat., thus resulting in partial trisomy 2Op and monosomy 4p. In addition, the amniotic fluid alpha-fetoprotein (AFP) became increasingly elevated with gestational age. The pregnancy was terminated at 25 weeks. The fetus presented with typical facial dysmorphic features, unilateral cleft lip and palate, severe renal hypoplasia, consistent with the 4p- (Wolf-Hirschhorn) syndrome. |
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| Keywords: | Prenatal diagnosis Fetal pathology Trisomy 20p Monosomy 4p |
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