|
|||||
|
|
Prenatal diagnosis of the fragile X using thymidine induction |
|
| Authors: | Grant R Sutherland Elizabeth Baker Stuart Purvis-Smith Athel Hockey Ed Krumins Sam Z Eichenbaum |
| Institution: | 1. Cytogenetics Unit, Adelaide Children's Hospital, North Adelaide, S.A. 5006, Australia;2. Cytogenetics Unit, Prince of Wales Hospital, Randwick, N.S.W. 2031, Australia;3. Genetic Counselling Clinic, King Edward Memorial Hospital for Women, Perth, W.A. 6000, Australia;4. Cytogenetics Unit, Royal Women's Hospital, Melbourne, Vic. 3000, Australia |
| Abstract: | Eleven pregnancies in ten patients at risk for the fragile X were monitored by amniocentesis or chorion villus biopsy and induction of the fragile site using thymidine, methotrexate and FUdR. Three female fetuses and one male fetus were found to have the fragile X. The results obtained using thymidine induction were superior to those using methotrexate induction and probably better than those obtained using FUdR induction. |
| Keywords: | Fragile X Prenatal diagnosis Thymidine Amniocentesis Chorion villus biopsy |