First-trimester prenatal diagnosis of severe alpha-thalassemia |
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| Authors: | Wang Liming Zhang Junwu Wu Guanyun Wang Shenwu Fan Yu Huang Youwen Zhao Letian Wang Rongxin Su Jidong Zhang Nijia Long Guifang Li Qi Zou Peng Liang Rong Liang Xu |
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| Affiliation: | 1. Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences 5, Dongdan Santiao, Beijing, China;2. 303 PLA Hospital Naming, Guangxi, China;3. Guangxi Medical College, Nanning, Guangxi, China |
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| Abstract: | ![]()
By means of chorion biopsy together with restriction endonuclease analysis of fetal DNA, first trimester diagnoses were successfully made in 33 fetuses at risk for Bart's hydrops fetalis. Seven pregnancies with Hb H or hydrops fetalis were therapeutically terminated before 4 months of gestation. Of the 26 pregnancies intended to continue, 18 have come to term with normal deliveries; one with threatened abortion was terminated at the end of the first trimester and, seven are progresssing normally. |
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| Keywords: | Chorion villus sampling Alpha-thalassemia Prenatal diagnosis by DNA analysis |
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