Suppression of male reproduction in rats after exposure to sodium fluoride during early stages of development |
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Authors: | P Sreedhar Reddy T Pushpalatha P Sreenivasula Reddy |
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Institution: | (1) Department of Biotechnology, S.V. University, Tirupati, 517 502, India |
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Abstract: | Sodium fluoride (NaF), a widespread natural pollutant was given to sperm-positive female rats throughout gestation and lactation
at a dose of 4.5 and 9.0 ppm via drinking water. The neonates were allowed to grow up to 90 days on tap water, and then sperm
parameters, testicular steroidogenic marker enzyme activity levels, and circulatory hormone levels were studied. The sperm
count, sperm motility, sperm coiling (hypoosmotic swelling test), and sperm viability were decreased in experimental rats
when compared with controls. The activity levels of testicular steroidogenic marker enzymes (3β hydroxysteroid dehydrogenase
and 17β hydroxysteroid dehydrogenase) were significantly decreased in experimental animals indicating decreased steroidogenesis.
The serum testosterone, follicle stimulating hormone and luteinizing hormone levels were also significantly altered in experimental
animals. Our data indicate that exposure to NaF during gestation and lactation affects male reproduction in adult rats by
decreasing spermatogenesis and steroidogenesis. |
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Keywords: | Sodium fluoride Sperm analysis Gestation and lactation 3β -HSD and 17β -HSD activity levels Serum testosterone |
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