珠江流域人群对典型EDCs的暴露及致癌风险评价

研究以珠江流域为例,结合美国EPA致癌风险评估模型,通过构建多介质-多途径暴露模型,定量评估了该区域居民暴露于镉(Cd)、滴滴涕(DDT)和多氯联苯(PCBs)等典型EDCs污染物的致癌风险,分析风险来源、暴露介质及暴露途径,并探讨不同环境介质的致癌风险贡献率.结果表明:Cd、DDT和PCBs的暴露剂量达2.36×10-4,6.46×10-5,4.62×10-5mg/(kg·d);暴露途径中经口摄入是最主要途径;总致癌风险为2.04×10-4,高于国内外所规定的可接受致癌风险水平上限(1×10-4),环境介质中蔬菜和大米对致癌风险贡献较大,区域主要典型EDCs污染物Cd和PCBs对致癌风险贡献率较大(分别达44%、45%).

Population exposure and cancer risk assessment of typical EDCs in Pearl River.

Potential cancer risk to human beings caused by typical endocrine disrupting chemicals (EDCs), including Cd, DDT and polychlorinated biphenyls (PCBs), in Pearl River Basin was investigated based on the US EPA guidelines for carcinogen risk assessment. The risk sources, exposure media and pathways, as well as the risk contribution from each component, were analyzed through the multi-media/multi-pathway human exposure model. Results showed that the daily exposure doses of Cd、DDT and PCBs to the residents in Pearl River Basin were 2.36′10-4, 6.46′10-5, 4.62′10-5mg/(kg·d), respectively, which were englobed mainly by oral intake. The total cancer risk was 2.04′10-4that was higher than the highest acceptable cancer risk level (1′10-4). Vegetables and rice were the major exposure media. Cd and PCBs were the dominant contributors to cancer risk, accounting for 44% and 45% , respectively.