| Abstract: | The peroxynitrite/porphyrin biomimetic system was established to investigate the effects of peroxynitrite on benzoa]pyrene (Ba]P) metabolism. Through the comparison of three model systems consisting of different iron porphyrins, we found that the peroxynitrite/T(p-Cl)PPFeCl system showed the highest catalytic efficiency in the metabolism of Ba]P. We analyzed the Ba]P metabolites produced from this system by RP-HPLC method and firstly identified the formation of nitrobenzoa]pyrenes which are the special metabolites of Ba]P induced by peroxynitrite. |
