Screening of hydrophobic DNA adducts in flounder (Platichthys flesus) from the Baltic Sea |
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| Institution: | 1. Laboratory of Aquatic Pathobiology, Department of Biology, Åbo Akademi University, BioCity, Artillerigatan 6, FIN-20520 Åbo, Finland;2. Estonian Institute of Experimental and Clinical Medicine, Hiiu 42, 11619 Tallinn, Estonia;3. vTI Institute of Fishery Ecology, Deichstraβe12, D-27472 Cuxhaven, Germany;1. Emerging Pathogens Institute, University of Florida, Gainesville, FL 32611, USA;2. Fisheries and Aquatic Sciences, University of Florida, Gainesville, FL 32653, USA;3. Shcool of Health and Life Sciences, Teesside University, Middlesbrough TS1 3BX, UK;4. Florida Fish and Wildlife Conservation Commission, Gainesville, FL 32601, USA;1. INRA, UMR1324 Centre des Sciences du Goût et de l’Alimentation, F-21000 Dijon, France;2. CNRS, UMR6265 Centre des Sciences du Goût et de l’Alimentation, F-21000 Dijon, France;3. Université de Bourgogne, UMR Centre des Sciences du Goût et de l’Alimentation, F-21000 Dijon, France;4. INRA, UMR1083 Sciences Pour l’Oenologie, F-34060 Montpellier, France;5. Montpellier SupAgro, UMR1083 Sciences Pour l’Oenologie, F-34060 Montpellier, France;6. Université Montpellier I, UMR1083 Sciences Pour l’Oenologie, F-34060 Montpellier, France;7. Synchrotron SOLEIL, F-91192 Gif Sur Yvette, France;8. INRA, CEPIA, UAR1008, F-44316 Nantes, France;1. Department of Chemistry, Faculty of Natural and Agricultural Science, University of the Free State, Bloemfontein, 9301, South Africa;2. Department of Microbial, Biochemical and Food Biotechnology, University of Free State, Bloemfontein, 9301, South Africa;1. Marine Science and Engineering College, Qingdao Agricultural University, Qingdao 266109, China;2. Jiangsu Provincial Key Laboratory of Coastal Wetland Bioresources and Environmental Protection, Jiangsu Key Laboratory for Bioresources of Saline Soils, Jiangsu Synthetic Innovation Center for Coastal Bio-agriculture, College of Ocean and Bioengineering, Yancheng Teachers University, Yancheng 224051, China;1. The Australian Wine Research Institute, PO Box 197, Glen Osmond, SA 5064, Australia;2. Metabolomics Australia, PO Box 197, Glen Osmond, SA 5064, Australia |
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| Abstract: | Neoplasia and other histopathological lesions in flounder (Platichthys flesus) liver have been investigated in several European sea areas, including the Baltic Sea. Several studies have been able to link neoplasm epizootics in fish with the exposure to genotoxins such as polycyclic aromatic hydrocarbons (PAHs). The level of hydrophobic DNA adducts in tissue DNA reflects the exposure of the organism to PAHs.Using hydrophobic DNA adduct levels as biomarkers, possible PAH exposure was assessed in flounder from 10 different sites in the Baltic Sea, collected during the years 1995–1997. The results show that the overall levels of hepatic DNA adducts were low and, in general, the chromatograms appeared clean. The highest levels of DNA adducts were found at two sites in the southern Baltic Sea. There were no statistically significant differences in adduct levels between the sites. Our results indicate that flounder from studied off shore sites of the Baltic Sea had not been exposed to a greater extent to large polycyclic hydrophobic hydrocarbons in their environment. |
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