| N-亚硝基二甲胺(NDMA)的环境过程和毒理效应 |
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| 引用本文： | 古楠,刘永东,钟儒刚.N-亚硝基二甲胺(NDMA)的环境过程和毒理效应[J].生态毒理学报,2013,8(3):338-343. |
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| 作者姓名： | 古楠 刘永东 钟儒刚 |
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| 作者单位： | 北京工业大学生命科学与生物工程学院,北京,100124 |
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| 基金项目： | 国家环保公益项目子课题"环境致癌物N-亚硝胺人体健康水质基准的研究"(2010467032) |
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| 摘 要： | N-亚硝基二甲胺(NDMA)是一种工业和环境污染物,具有强烈的致癌、致畸和致突变毒性;实验证明它可导致动物很多器官包括肝脏、肺和肾脏的癌症;它几乎无处不在,广泛分布于人类的生活环境中,已引起了人们的高度重视。在综合了大量文献的基础上,充分总结了NDMA的物理和化学性质、来源、毒理学信息和暴露途径等,并就研究中尚未解决的问题作了讨论,以期为NDMA的人类毒理效应研究以及各类标准的制定提供科学依据。
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| 关 键 词： | N-亚硝基二甲胺 暴露途径 毒性效应 |
| 收稿时间： | 2012/8/21 0:00:00 |
| 修稿时间： | 2012/10/25 0:00:00 |
Environment Process and Toxicological Effects of N-Nitrosodimethylamine (NDMA) |
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| Gu Nan,Liu Yongdong and Zhong Rugang.Environment Process and Toxicological Effects of N-Nitrosodimethylamine (NDMA)[J].Asian Journal of Ecotoxicology,2013,8(3):338-343. |
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| Authors: | Gu Nan Liu Yongdong and Zhong Rugang |
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| Institution: | College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China;College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China;College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China |
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| Abstract: | N-nitrosodimethylamine (NDMA) is an industrial and environmental pollutant. It has strong carcinogenic, mutagenic and teratogenic effects. NDMA was demonstrated to cause cancers in organs, including liver, lung, and kidney in animals. It aroused great attention resulting from its wide distribution in the environment. The physical and chemical properties of NDMA, its origins and toxicological data were fully summarized as well as its exposure approach. Additionally, some unsolved problems in this area were discussed. This review aims to provide a theoretical basis for the study of toxic effects of NDMA on human and formulating national standards of China. |
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| Keywords: | N-nitrosodimethylamine (NDMA) exposure approach toxicity |
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