Biodegradable Microspheres for Controlled Release of an Antibiotic Ciprofloxacin |
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Authors: | S Ravindra K Varaprasad N Narayana Reddy K Vimala K Mohana Raju |
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Institution: | (1) Synthetic Polymer Laboratory, Department of Polymer Science and Technology, Sri Krishnadevaraya University, Anantapur, A.P., 515055, India; |
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Abstract: | Ciprofloxacin (CF) loaded biodegradable microspheres of Poly(lactide-co-caprolactone)-PF127 (a poloxamer block copolymer of Ethylene Oxide/Propylene Oxide) were prepared by using solvent evaporation
technique. The microspheres were characterized by differential scanning calorimetry (DSC) and X-ray diffractometry (X-RD)
technique to confirm the polymorphism of ciproflaxacin (CF) drug. The X-RD and DSC techniques indicated molecular level dispersion
of CF in the microspheres. Scanning electron micrographic images (SEM) of the microspheres indicated smooth surfaces of the
spherical microspheres. Cumulative release characteristics of the matrices for CF, the antibiotic drug, were investigated
in pH 7.4 media. It was possible to release CF in controlled manner up to 72 h. The developed ciprofloxacin loaded Poly(lactide-co-caprolactone)-PF127
microspheres were evaluated for preliminary antibacterial applications. |
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Keywords: | |
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