Reduced sperm quality in relation to oxidative stress in red deer from a lead mining area |
| |
| Authors: | Manuel M Reglero Mark A Taggart Pilar Castellanos Rafael Mateo |
| |
| Institution: | 1. Division of Reproduction, Department of Clinical Sciences, P.O. Box 7054, Swedish University of Agricultural Sciences, SLU, SE-750 07 Uppsala, Sweden;2. Department of Surgery and Theriogenology, Khon Kaen University, Khon Kaen 40002, Thailand;1. College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China;2. Department of Heavy Ion Radiation Medicine, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou 730000, China;3. Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China;4. Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, China;5. Lanzhou Agricultural Science and Technology Research Promotion Center, Lanzhou 730030, China;1. College of Environmental and Municipal Engineering, Qingdao Technological University, Qingdao 266033, China;2. Key Laboratory of Marine Spill Oil Identification and Damage Assessment Technology, North China Sea Environmental Monitoring Center of State Oceanic Administration, Shandong, Qingdao 266033, China;1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait;2. Department of Microbiology, Faculty of Medicine, Kuwait University, P.O. Box 24923, Safat 13110, Kuwait |
| |
| Abstract: | We studied the effects of elevated heavy metal uptake on the sperm quality and the antioxidant mechanisms of sperm and testis of red deer from a Pb mining area in Spain. Testis, liver and bone of red deer from mining (n = 21) and control (n = 20) areas were obtained from hunters and analyzed for Pb, Zn, Cu, Cd, As and Se. Testes were weighed and measured. Motility, acrosome integrity and viability and functionality of membrane were evaluated in epididymal spermatozoa. Lipid peroxidation, total glutathione, glutathione peroxidase (GPX) and superoxide dismutase (SOD) were studied in testis and spermatozoa. Deer from mined areas showed less Cu in testis, a higher testis mass and size and reduced spermatozoa membrane viability and acrosome integrity. Effects on sperm quality were associated to decreased Cu and increased Se in testis, and to decreases in the activity of SOD and GPX in testis and spermatozoa. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
