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Sodium arsenate induce changes in fatty acids profiles and oxidative damage in kidney of rats |
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| Authors: | Wafa Kharroubi Madiha Dhibi Manel Mekni Zohra Haouas Imed Chreif Fadoua Neffati Mohamed Hammami Rachid Sakly |
| Institution: | 1. Laboratory of Nutrition-Functional Foods and Vascular Diseases, Faculty of Medicine, University of Monaster, Monastir, 5019, Tunisia 3. Laboratory of Histology and Cytogenetic, Faculty of Medicine, University of Monaster, Monastir, 5019, Tunisia 2. Department of Biochemistry CHU Fattouma Bourguiba, University of Monaster, Monastir, 5019, Tunisia |
| Abstract: | Six groups of rats (n?=?10 per group) were exposed to 1 and 10 mg/l of sodium arsenate for 45 and 90 days. Kidneys from treated groups exposed to arsenic showed higher levels of trans isomers of oleic and linoleic acids as trans C181n-9, trans C18:1n-11, and trans C18:2n-6 isomers. However, a significant decrease in eicosenoic (C20:1n-9) and arachidonic (C20:4n-6) acids were observed in treated rats. Moreover, the “Δ5 desaturase index” and the saturated/polyunsaturated fatty acids ratio were increased. There was a significant increase in the level of malondialdehyde at 10 mg/l of treatment and in the amount of conjugated dienes after 90 days (p?p?p?p?n-6 polyunsaturated fatty acids and leads to an increase in the trans FAs isomers. Therefore, FA-induced arsenate kidney damage could contribute to trigger kidney cancer. |
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