Neurotoxicology of ortho-substituted polychlorinated biphenyls |
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Authors: | Richard F Seegal Brian Bush William Shain |
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Institution: | Richard F. Seegal*, Brian Bush,William Shain |
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Abstract: | Ortho-substituted, non-planar PCBs reduce dopamine content in both nonhuman primate brain and pheochromocytoma (PC12) cells. Planar, dioxin-like, congeners have no effect on dopamine content in PC12 cells. Additional in-vitro results indicate that dopamine reduction by PCBs is due to inhibition of tyrosine hydroxylase activity. |
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