1,2,5,6-四溴环辛烷(TBCO)的分析方法、环境行为及毒性效应研究进展

1，2，5，6-四溴环辛烷（1，2，5，6-Tetrabromocyclooctane，TBCO）与六溴环十二烷（HBCD）同属于脂环族溴代阻燃剂.随着HBCD的禁止生产和限制使用，TBCO成为潜在的替代品，其生态和环境效应开始受到关注.通过对TBCO的性质、分析方法、环境行为和毒性效应研究进行综述，结果表明:TBCO具有2个非对映异构体（简称为异构体），分别为α-TBCO和β-TBCO，其中β-TBCO有一对对映体；TBCO的检测一般采用气相色谱-质谱联用法；TBCO目前已在空气、土壤、沉积物及生物中检出，并显示出生物蓄积性、生物毒性以及异构体特异性的生物降解.需要指出的是，关于环境介质、生物体中TBCO的有限研究主要集中于水生生态系统，在陆生生态系统中的生物富集、食物链放大及毒性效应的研究非常匮乏.TBCO是否具有环境持久性和长距离传输能力尚存争议.建议全面开展TBCO的环境界面迁移行为、生物富集、代谢与毒性效应研究，特别是在陆生生态系统中的研究，并从异构体和对映体水平深入探讨，以期全面评价TBCO的生态和健康风险. 

Analytical Methods,Environmental Behaviors and Toxicological Effects of 1, 2, 5, 6-Tetrabromocyclooctane (TBCO)

1, 2, 5, 6-tetrabromocyclooctane (TBCO) and hexabromocyclododecane (HBCD) are both cycloaliphatic brominated flame retardants. With the ban on production and the restriction on use of HBCD, TBCO is expected to become a potential substitute, which raises concerns about its ecological and environmental impact. The properties, analytical methods, environmental behavior, and toxicological effect of TBCO are reviewed. TBCO consists of two diastereoisomers, α-TBCO and β-TBCO, of which β-TBCO has a pair of enantiomers. TBCO is usually detected by gas chromatography-mass spectrometry (GC-MS). Up to now, TBCO has been detected in air, soil, sediment, and organisms, and has shown bioaccumulation, biotoxicity, and isomer-specific biodegradation. It should be pointed out that the current limited studies on TBCO in the environment and organisms are mainly focused on aquatic ecosystems. There is very little understanding of the biological enrichment, biomagnification in the food chain, and toxicological effects of TBCO in terrestrial ecosystems. Whether TBCO has environmental persistence and long-range transport potential remains controversial. In order to comprehensively evaluate the ecological and health risks of TBCO, it is essential to explore the environmental interfacial migration, transformation, bioaccumulation and toxicological effects of TBCO, especially in the terrestrial system at the levels of diastereomer and enantiomer.