Serum and follicular fluid concentrations of polybrominated diphenyl ethers and in-vitro fertilization outcome |
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| Institution: | 1. Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA;2. Department of Environmental Health, Harvard School of Public Health, 677 Huntington Ave., Boston, MA 02115, USA;3. Environmental Health and Engineering, Inc., 117 Fourth Avenue, Needham, MA 02494, USA;4. Obstetrics, Gynecology and Reproductive Biology, Brigham and Women''s Hospital, 75 Francis St., Boston, MA 02115, USA;1. Bladder Cancer Center, Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA 02115, USA;2. Urology Department, Fundacio Puigvert, Cartagena 340-350, Barcelona 08025, Spain;3. Urology Department, Instituto Valenciano de Oncologia, Calle del Profesor Beltrán Bàguena, 8, València 46009, Spain;1. Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China;2. Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China;3. Reproductive Medicine Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095, Jiefang Avenue, Wuhan, Hubei, PR China;1. Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China;2. Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China;3. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA;4. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA;5. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA;6. School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China;7. Department of Gynecology and Obstetrics, Xiaonan Maternal and Child Care Service Centre, Xiaogan City, Hubei, PR China;8. Wuhan Center for Disease Prevention and Control, Wuhan, Hubei, PR China;1. Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China;2. Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental health (incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China;3. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China;1. Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, State Key Laboratory of Environmental Health (incubating), Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China;2. Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Xiangyang No.1 People''s Hospital, Hubei University of Medicine, Xiangyang, Hubei, PR China;3. Wuhan Center for Disease Prevention and Control, Wuhan, Hubei, PR China;4. Department of Pathology, Bengbu Medical College, Anhui, PR China;5. Departments of Nutrition and Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA;6. Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN, USA |
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| Abstract: | There is evidence of endocrine disruption and reproductive effects in animals following exposure to certain PBDEs, but human studies are limited. The goal of this study was to investigate the use of serum and follicular fluid as biomarkers of exposure to PBDEs and to explore whether a relationship between PBDE exposure and early pregnancy loss exists. We measured 8 PBDE congeners in archived serum and ovarian follicular fluid samples from 65 women undergoing in-vitro fertilization (IVF). Logistic regression models were used to predict the odds of failed embryo implantation associated with higher levels of PBDEs among the women in the study. There were moderate Kendall's Tau-beta correlations between serum and follicular fluid concentrations of BDE 28, 47, 100 and 154 (Tβ = 0.29–0.38, all p-values < 0.005), but BDE 99 and 153 were not correlated between the two matrices (Tβ < 0.2, p-values > 0.05). Women with detectable concentrations of BDE 153 (39% had detectable levels) in follicular fluid had elevated odds of failed implantation compared with women who had non-detectable concentrations (adjusted OR = 10.0; 95%CI: 1.9 to 52; p = 0.006; adjusted by age and body mass index). These findings suggest that exposure to BDE 153 may be associated with failed embryo implantation. Due to our observation of only moderate correlations between matrices, serum PBDE concentrations may not be a good indicator of follicular fluid concentrations when studying early pregnancy endpoints in women undergoing IVF. |
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