Effect of hydrogen sulfide in comparison to atorvastatin on endothelial damage in cholesterol-fed rabbits |
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| Authors: | Manar A Nader Nariman M Gameil Dina S El-Agamy Dalia H El-Kashef |
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| Institution: | 1. Pharmacology &2. Toxicology Department, Pharmacology and Toxicology College of Pharmacy, Taibah University, Saudi Arabia;3. Pharmacology &4. Toxicology Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egyptmanarahna@yahoo.com manarahna@mans.edu.eg;6. Toxicology Department, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt |
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| Abstract: | Hydrogen sulfide (H2S) is an endogenous gaseous molecule, functioning as a physiological regulator. This study aimed to investigate the role of H2S in atherosclerosis. Rabbits receiving high cholesterol were given atorvastatin (10 mg/kg/day, orally) or sodium sulfide (1.1 mg/kg/day, intramuscular) 2 weeks after commencement of high-cholesterol diet and continued for 4 weeks. Serum lipid profiles, lipid peroxidation indexed as malondialdehyde, glutathione, superoxide dismutase, the vascular adhesion molecule-1, and aortic vascular endothelial growth factor were determined. Rabbits receiving a high-cholesterol diet showed elevated levels of total serum cholesterol, triglycerides, low-density lipoprotein cholesterol, malondialdehyde and vascular adhesion molecule-1, and aortic vascular endothelial growth factor expression and lower levels of high-density lipoprotein cholesterol, glutathione, and superoxide dismutase. Treatment with atorvastatin and sodium sulfide has beneficial effects on serum lipid profile, oxidative damage, vascular adhesion molecule-1, and aortic expression of vascular endothelial growth factor. |
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| Keywords: | sodium sulfide high-cholesterol diet vascular damage aorta |
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