The protective potential of Nitraria retusa on penconazole-induced hepatic injury in adult rats |
| |
| Authors: | Mariem Chaâbane Nejla Soudani Khawla Benjeddou Mouna Turki Fatma Ayadi Makni Tahia Boudawara |
| |
| Institution: | 1. Enzymes and Bioconversion Unit, National Engineering School of Sfax, Sfax, University of Sfax, Tunisia;2. Animal Physiology Laboratory, Department of Life Sciences, University of Sfax, Sciences Faculty of Sfax, Sfax, Tunisia;3. Animal Physiology Laboratory, Department of Life Sciences, University of Sfax, Sciences Faculty of Sfax, Sfax, Tunisia;4. Biochemistry Laboratory, University of Sfax, CHU Habib Bourguiba, Sfax, Tunisia;5. Histopathology Laboratory, University of Sfax, CHU Habib Bourguiba, Sfax, Tunisia |
| |
| Abstract: | The protective effect of Nitraria retusa fruit extract against hepatotoxicity induced by penconazole at a dose of 67 mg/kg body weight given intraperitoneally every two days to male Wistar rats was investigated. Penconazole exposure increased malondialdehyde, hydrogen peroxide, and advanced oxidation protein product levels. Hepatic biomarkers as well as enzymatic (catalase, superoxide dismutase and glutathione peroxidase) and nonenzymatic (vitamin C, non-protein thiols and metallothioneins) antioxidant status were also altered. Treatment with N. retusa extract improved all parameters cited above. Liver histological studies confirmed the biochemical parameters. These results provide a scientific basis for the use of N. retusa fruit against hepatotoxicity. |
| |
| Keywords: | penconazole hepatotoxicity rats Nitraria retusa fruit |
|
|
