Sub-chronic oral toxicity of acetamiprid in Wistar rats |
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Authors: | RK Shakthi Devan Akhilesh Mishra PC Prabu TK Mandal |
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Institution: | 1. Central Animal Facility, SASTRA University, Thanjavur, India;2. Department of Pharmacology and Toxicology, West Bengal University of Animal and Fishery Sciences, Kolkata, India |
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Abstract: | Acetamiprid is a neoncotinoid insecticide that acts as an agonist to the nicotinic acetylcholine receptor used as insecticide in crops and to control fleas on dogs and cats. The objectives of this study are (1) to evaluate the sub-chronic toxicity of orally administered acetamiprid, (2) to estimate the tissue residue levels and (3) to assess the reactive oxygen species induction in Wistar rats. Clinical signs of toxicity and changes in the haematological parameters were not observed in the acetamiprid-treated groups. Biochemically, increases in the levels of alanine aminotransferase, aspartate aminotransferase, cholesterol and decreases in body weight, feed consumption, reduced glutathione, catalase, superoxide dismutase, glutathione peroxidase, and AchE were observed. Lipid peroxidation was increased in liver and kidney. Acetamiprid residues persisted in liver, kidney, spleen, muscles, brain, fat and histopathology revealed lesions in the liver. The no observable adverse effect level of acetamiprid was found to be ≤55 mg/kg body weight. |
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Keywords: | neonicotinoids toxicity tissue residues reactive oxygen species lipid peroxidation reduced glutathione catalase superoxide dismutase glutathione peroxidase and rats |
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