Benzo[a]pyrene exposure influences the cardiac development and the expression of cardiovascular relative genes in zebrafish (Danio rerio) embryos |
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Authors: | Huang Lixing Wang Chonggang Zhang Youyu Li Jian Zhong Yuanfu Zhou Yulin Chen Yixin Zuo Zhenghong |
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Institution: | a Key Laboratory of Ministry of Education for Subtropical Wetland Ecosystem Research, School of Life Sciences, Xiamen University, Xiamen, China b State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, China c Prenatal Diagnosis Center of Xiamen, Maternal and Child Health Hospital of Xiamen, Xiamen, Fujian, China |
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Abstract: | It is reported that the most abundant polycyclic aromatic hydrocarbons (PAHs) in weathered crude oils are cardiotoxic. However, the action mechanism of PAHs on vertebrate cardiovascular development and disease is unclear. In the present study, the cardiac morphology and functioning of zebrafish embryos exposed to benzoa]pyrene B(a)P], as a high-ring PAHs, for 72 h were observed and determined. The results showed that B(a)P exposure resulted in cardiac developmental defects in zebrafish embryos. Significant changes in expression level of multiple genes potentially critical for regulating the B(a)P-induced cardiovascular developmental defects were also found. A gene network regulating cardiac development perturbed by B(a)P exposure was identified and established by computational analysis and employment of some databases. The information from the network could provide a clue for further mechanistic studies explaining molecular events regulating B(a)P-mediated cardiovascular defects and consequences. |
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Keywords: | B(a)P Cardiac toxicity Embryonic development Gene regulatory networks Microarray Zebrafish |
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