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Comparisons of polybrominated diphenyl ethers levels in paired South Korean cord blood, maternal blood, and breast milk samples |
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| Authors: | Kim Tae Hyung Bang Du Yeon Lim Hyun Jung Won A Jin Ahn Mee Young Patra Nabanita Chung Ki Kyung Kwack Seung Jun Park Kui Lea Han Soon Young Choi Wahn Soo Han Jung Yeol Lee Byung Mu Oh Jeong-Eun Yoon Jeong-Hyun Lee Jaewon Kim Hyung Sik |
| Institution: | a Laboratory of Molecular Toxicology, MRC Center and College of Pharmacy, Pusan National University, San 30, Jangjeon-dong, Geumjeung-gu, Busan 609-735, South Korea b Division of Toxicology, College of Pharmacy, Sungkyunkwan University, Chunchun-dong 300, Changan-ku, Gyeonggi-do, Suwon 440-746, South Korea c National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration, Seoul, South Korea d The Korean Motherisk Program, Cheil Hospital & Women’s Health-care Center, Kwandong University, College of Medicine, Seoul, South Korea e Department of Immunology and Physiology, College of Medicine, Konkuk University, Chungju, South Korea f Department of Civil and Environmental Engineering, Pusan National University, San 30, Jangjeon-dong, Geumjeong-gu, Busan 609-735, South Korea |
| Abstract: | Polybrominated diphenyl ethers (PBDEs), commonly used flame retardants, have been reported as potential endocrine disruptor and neurodevelopmental toxicants, thus giving rise to the public health concern. The goal of this study was to investigate the relationship between umbilical cord blood, maternal blood, and breast milk concentrations of PBDEs in South Korean. We assessed PBDE levels in paired samples of umbilical cord blood, maternal blood, and breast milk. The levels of seven PBDE congeners were measured in 21 paired samples collected from the Cheil Woman’s Hospital (Seoul, Korea) in 2008. We also measured thyroid hormones levels in maternal and cord blood to assess the association between PBDEs exposure and thyroid hormone levels. However, there was no correlation between serum thyroxin (T4) and total PBDEs concentrations. The total PBDEs concentrations in the umbilical cord blood, maternal blood, and breast milk were 10.7 ± 5.1 ng g−1 lipid, 7.7 ± 4.2 ng g−1 lipid, and 3.0 ± 1.8 ng g−1 lipid, respectively. The ranges of total PBDE concentrations observed were 2.28-30.94 ng g−1 lipid in umbilical cord blood, 1.8-17.66 ng g−1 lipid in maternal blood, and 1.08-8.66 ng g−1 lipid in breast milk. BDE-47 (45-73% of total PBDEs) was observed to be present dominantly in all samples, followed by BDE-153. A strong correlation was found for major BDE-congeners between breast milk and cord blood or maternal blood and cord blood samples. The measurement of PBDEs concentrations in maternal blood or breast milk may help to determine the concentration of PBDEs in infant. |
| Keywords: | BDE brominated diphenyl ether PBDEs polybrominated diphenyl ethers SPE solid phase extraction T4 thyroxine TSH thyroid stimulating hormone |
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