The effects of 3,3′,4,4′-tetrabromobiphenyl on rats fed diets containing a constant level of copper and varying levels of molybdenum |
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Authors: | Kadhim N Salman Mary A Stuart Jack Schmidt T Borges Craig J McClain Farrel R Robinson Miao Li Larry W Robertson |
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Institution: | 1. Graduate Center for Toxicology, University of Kentucky, Lexington, KY, 40536, USA 2. Department of Nutrition and Food Science, University of Kentucky, Lexington, KY, 40506, USA 3. Department of Medicine, Veterans Administration Medical Center, Lexington, KY, 40511, USA 4. Oak Ridge National Laboratory, Oak Ridge, TN, 37830, USA 5. Departments of Medicine, and Pharmacology and Toxicology, University of Louisville, Louisville, KY, 40292, USA 8. Department of Medicine, Robley Rex Louisville VAMC, Louisville, KY, 40206, USA 6. Animal Disease Diagnostic Laboratory, Purdue University, West Lafayette, IN, 47907, USA 7. Interdisciplinary Graduate Program in Human Toxicology, University of Iowa, Iowa City, IA, 52242, USA 9. Department of Occupational and Environmental Health, College of Public Health, The University of Iowa, 100 Oakdale Campus #219 IREH, Iowa City, IA, 52242-5000, USA
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Abstract: | Copper (Cu) metabolism is altered in rats fed diets high in molybdenum (Mo) and low in Cu. This 10-week study was carried out to examine the effects of supplemental Mo (7.5–240 μg/g diet) on male Sprague–Dawley rats fed diets adequate in Cu (5 μg/g diet) and to determine the susceptibility of Mo-treated animals to the environmental pollutant 3,3′,4,4′-tetrabromobiphenyl (TBB). After 7 weeks of dietary treatment, half of the rats in each group received a single IP injection of TBB (150 μM/kg bw), while the other half received the corn oil vehicle. Rats sacrificed at 10 weeks showed no effects of Mo on growth, feed efficiency, or selected organ or tissue weights. Dose-dependent effects on plasma Mo (0–5.1 μg/mL), plasma Cu (0.95–0.20 μg/mL), and bone Cu (3.4–10 μg/g) in control through the high dose were found. Cu sequestration in the bone of Mo-treated rats is a new finding. TBB treatment resulted in dramatic weight loss and loss of absolute organ mass. Relative organ weights were increased, except for the thymus. TBB altered the concentrations of certain amino acids. Compared to control rats, this polybrominated biphenyl congener significantly decreased plasma Cu and ceruloplasmin at higher concentrations of dietary Mo and promoted the process of plasma Cu decrease by Mo, suggesting a combined effect. |
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