| 全氟羟基物质在冠海豹(Hooded seals)体内的母源性传递 |
| |
| 作者姓名： | - |
| |
| 摘 要： | 在野生动物物种中，乳汁在传递全氟烃基物质(PFASs)于后代中所起的作用，人类还了解甚少。本文以雌性冠海豹及其生产的一对幼崽为研究对象，在哺乳期间，对母体血浆和乳汁中的8种PFASs进行了定量检测，以及对乳汁在PFASs传递过程中所起的作用进行了分析。选择冠海豹是因为它的泌乳周期短(3~ 4 d)，在此期间幼崽仅以乳汁为食。胎盘或乳汁传递成为幼崽体内PFASs的唯一来源。通过对8种PFASs的分析(Σ8PFAS)，发现7种存在于所有样品中；因此，乳汁是幼崽体内PFASs的来源。在所有样本中，全氟辛烷磺酰基化合物是优势PFAS。Σ8PFAS的平均浓度为母体血浆中6.0 ng/g蛋白(36 ng/g湿重)，乳汁中0.77 ng/g蛋白(3.2 ng/g湿重)以及幼崽血浆中12 ng/g蛋白(66 ng g湿重)。血浆中检测到的PFASs浓度在已有报道的其他海豹物种体内检测到的浓度范围之内，低于已知的实验啮齿动物的毒性阈值。PFASs从母体到幼崽的传递效率的个体差异，依赖于PFASs碳键长度、相对传递量最低的为中间能级键的PFASs (C9-C10)。结果显示母体通过乳汁和胎盘传递PFASs，其中胎盘传递是主导途径。
精选自Randi Gr?nnestad, Gro D. Villanger, Anuschka Polder, Kit M. Kovacs, Christian Lydersen, Bj?rn M. Jenssen, Katrine Borg?. Maternal transfer of perfluoroalkyl subastances in hooded seals. Environmental Toxicology and Chemistry: Volume 36, Issue 3, pages 763–770, July 2017.
DOI: 10.1002/etc.3623
详情请见http://onlinelibrary.wiley.com/wol1/doi/10.1002/etc.3623/full
|
Maternal Transfer of Perfluoroalkyl Subastances in Hooded Seals |
| |
| -.Maternal Transfer of Perfluoroalkyl Subastances in Hooded Seals[J].Asian Journal of Ecotoxicology,2017,12(2). |
| |
| Authors: | Randi Gr?nnesta Gro D Villanger Anuschka Polder Kit M Kovacs Christian Lydersen Bj?rn M Jenssen Katrine Borg? |
| |
| Institution: | 1. Department of Biosciences, University of Oslo, Oslo, Norway
2. Department of Child Development and Mental Health, Norwegian Institute of Public Health, Oslo, Norway
3. Norwegian University of Life Sciences, Oslo, Norway
4. North-West University, Potchefstroom, South Africa
5. Fram Centre, Norwegian Polar Institute, Troms?, Norway
6. Department of Biology, Norwegian University of Science and Technology, Trondheim, Norway |
| |
| Abstract: | |
| |
| Keywords: | Arctic Milk Placental transfer Perfluorooctane sulfonate Perfluoroalkyl substance |
|
| 点击此处可从《生态毒理学报》浏览原始摘要信息 |
| 点击此处可从《生态毒理学报》下载免费的PDF全文 |
|
