Biochemical effects of long term exposure to Cr,Cd,Ni on rainbow trout (Salmo gairdneri Rich.) : Influence of sex and season

$\text{Salmo gairdneri}$ specimens were exposed for 6 months to low concentrations of Cr,Cd,Ni, and their mixture. Treated animals, particularly males, showed an impairment in glucidic metabo - lism, a modification in lysosomal function, and alterations in gill sialic acid content.Some of these alterations persist in males after 3 month recovery, with only exception for Ni - treated animals.A connection between sex, seasonal cycle, and biochemical response to metal pollution was observed.