Gestational exposure to hydroxyprogesterone caproate suppresses reproductive potential in male rats |
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Authors: | T Pushpalatha P Ramachandra Reddy P Sreenivasula Reddy |
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Institution: | (1) Department of Biotechnology, S.V. University, 517 502 Tirupati, India |
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Abstract: | Hydroxyprogesterone caproate was administered to pregnant rats at a dose level of 10 and 25 mg/kg body weight on 1st, 7th
and 14th gestational day and the male pups (F1 generation) were allowed to grow for 90 days. The effect of gestational exposure
to hydroxyprogesterone caproate on fertility was assessed by breeding F1 male rats with control female rats besides analyzing
sperm quality and quantity in F1 male rats. The number of implantation sites and viable fetuses was significantly reduced
in females mated with F1 males that were exposed to hydroxyprogesterone caproate during embryonic development. The decrease
in sperm function was associated with a decrease in sperm motility, sperm viability and sperm count in F1 rats. The study
clearly indicates that in utero exposure to hydroxyprogesterone caproate affects fertility in male rats. |
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