Biotic transformation of anticoccidials in soil using a lab-scale bio-reactor as a precursor-tool |
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| Authors: | Hansen Martin Björklund Erland Krogh Kristine A Brandt Asbjørn Halling-Sørensen Bent |
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| Affiliation: | a Section of Toxicology and Environmental Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark
b Section of Veterinary Medicines, The Danish Medicines Agency, Axel Heides Gade 1, DK-2300 Copenhagen, Denmark |
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| Abstract: | Two anticoccidial agents, salinomycin and robenidine, heavily used in the worldwide veterinary meat production, were investigated for their potential biotic degradation by cultured soil bacteria. The degradation-study was performed in lab-scale bio-reactors under aerobic and anaerobic conditions incubated for 200 h with a mixed culture of soil bacteria. Samples were analyzed by LC-MS/MS and potential transformation products were tentatively identified. Salinomycin was degraded under aerobic conditions and traces could be found after 200 h, however, seems more persistent under anaerobic conditions. Four transformation products of salinomycin were discovered. Robenidine was degraded under aerobic and anaerobic conditions, however, traces of robenidine were observed after 200 h. Five biotic transformation products of robenidine were discovered. |
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| Keywords: | Salinomycin Robenidine Aerobic Anaerobic Degradation Soil bacteria |
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