| 应用大鼠全胚胎培养方法探讨偏钒酸铵的致畸作用及其机理 |
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| 引用本文： | 刘洪波,孙棉龄.应用大鼠全胚胎培养方法探讨偏钒酸铵的致畸作用及其机理[J].四川环境,1995,14(3):35-39. |
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| 作者姓名： | 刘洪波 孙棉龄 |
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| 作者单位： | 华西医科大学环境卫生学教研室，四川生殖卫生学院遗传室 |
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| 摘 要： | 本文通过ＮＨ４ＶＯ３体外大鼠全胚胎培养致畸实验研究，发现ＮＨ４ＶＯ３对大鼠胚胎具有直接胚胎毒性和致畸性，且具有显的剂量一反应和时间一效应关系，其作用机理可能与卵黄囊的功能受到钒化物的损害有关。
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| 关 键 词： | 全胚胎培养 偏钒酸铵 致畸作用 动物实验 大鼠 |
Studies on the Teratogenic Effects of Ammonium Vanadate and Its Mechanism Using Whole Rat Embryo CuIture in Vitro |
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| Liu Hongbo,Sun Mianling,WuDesheng,Tan Zongqing.Studies on the Teratogenic Effects of Ammonium Vanadate and Its Mechanism Using Whole Rat Embryo CuIture in Vitro[J].Sichuan Environment,1995,14(3):35-39. |
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| Authors: | Liu Hongbo Sun Mianling WuDesheng Tan Zongqing |
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| Abstract: | This paper reported the experimental studies on cmbryotoxicity and teratogenicity of ammonium vanadate using post-imolantation whole rat embryo culture system in vitro. The results indicated that vanadium has direct embryotoxic and teratogeniceffects on tat pmbrycs with dose-response and time-effec relationships. The dysfunction of yolk sac induced by vanadium may bean importmant mechanism of its teratogenic action. |
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| Keywords: | Whole cmbryo culture ammonium vanadate teratogenic effect |
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