纳米颗粒物对肺表面活性物质界面性质的影响

以纳米二氧化硅、纳米碳粉、纳米氧化锌、纳米氧化铈、纳米碳化硅和纳米四氧化三铁等纳米颗粒物(NPs)为代表,研究其对肺表面活性物质(PS)界面性质的影响.结果表明,NPs对PS中的磷脂和蛋白组分均有吸附作用,其中纳米二氧化硅和纳米四氧化三铁分别对磷脂和蛋白组分的吸附能力最强,吸附率为89.3%和82.5%.NPs的存在会导致PS溶液的表面张力升高,这当中纳米二氧化硅的效果最为显著.纳米碳化硅和纳米二氧化硅等颗粒物会引起PS膜的π-A等温线的内缩/外扩,且颗粒物浓度越高,表面压力变化越明显.此外,PS也会对NPs的水合动力学直径和Zeta电位产生影响,导致其分散状态变化.由此可见,NPs可通过改变PS的组成和界面性质而具备危害人体健康的潜力.

Effect of nano-particles on interfacial chemical properties of pulmonary surfactant

Nano-particles (NPs) such as nano-silica, nano-carbon powder, nano-zinc oxide, nano-cerium oxide, nano-silicon carbide and nano-iron tetroxide were used as representatives to study their effects on the interface properties of pulmonary surfactant (PS). The results shown that NPs had adsorption effects on both phospholipid and protein components in PS, and nano-silica and nano-ferric tetroxide had the strongest adsorption capacity for phospholipid and protein components, respectively, with adsorption rates of 89.3% and 82.5%. The existence of NPs would lead to the increase of the surface tension of PS solution, among which the effect of nano-silica was the most significant. Particles such as nano-silicon carbide and nano-silicon dioxide can cause the inward shrinkage/outward expansion of the π-A isotherm of the PS film, and the higher the particle concentration, the more obvious the surface pressure change. In addition, PS also had an effect on the hydration kinetic diameter and Zeta potential of NPs, resulting in the change of its dispersion state. It can be seen that NPs can change the composition and interface of PS by changing the composition and interface of PS.