高硒高镉联合作用对大鼠谷胱甘肽过氧化物酶活性的影响

用人工合成饲料控制硒、镉含量饲养SD大鼠12周,观察高剂量硒(5.5mg/kg)和高剂量镉(20.4mg/kg)联合作用对大鼠血液、心、肝、肾、肺、脑和脾中谷胱甘肽过氧化物酶(GSH-px)活性的影响。实验结果表明,经口同时摄入高硒高镉,大鼠血液GSH-px活性显著增加,对单独摄入高硒或高镉所致血液GSH-px活性下降有明显拮抗,对组织GSH-px活性的影响则因脏器而异,在肝、肾和肺,主要表现为对硒单独染毒所致GSH-px活性下降有拮抗作用;脾脏表现为对硒或镉单独染毒所致GSH-px活性下降有拮抗作用,脑组织表现为硒镉共存使GSH-px活性显著下降。

Study on Combined Effects of High Dosages of Selenium and Cadmium Fed to Rats on GSH-px Activities in Blood and Tissues

The artificial synthesis diets were fed to SD rats for 12 weeks to examine the combined effects of high dosages of selenium(5.5mg/kg) and cadmium (20.4 mg/kg) on GSH-px activities in blood and tissues (heart, liver, kidney, lung, brain and spleen). The results showed that the blood GSH-px activities of rats fed ordally with high dosages of selenium and cadmium together increased significantly, and the decrease in blood GSH-px activities in rats fed orally with a high dosage of selenium or cadmium alone was antagonized. The decreases in GSH-px activities of liver, kidney, lung and spleen due to feeding orally with a high dosage of selenium or cadmium alone were antagonized by feeding orally with high dosages of selenium and cadmium simultaneously. But the administering orally with high dosages of selenium and cadmium led to a significant decrease in GSH-px activites in rats brain.