Department of Community Health Sciences, University of Calgary, Calgary, Canada;2. Department of Obstetrics and Gynaecology, University of Calgary, Calgary, Canada;3. Department of Medical Genetics, Alberta Children's Hospital, Calgary, Canada;4. Department of Community Health Sciences, University of Manitoba, Winnipeg, Canada;5. Department of Pathology and Laboratory Medicine, Saskatoon Health Region and College of Medicine, University of Saskatchewan, Saskatoon, Canada