镉对黑斑蛙脏器组织的亚慢性毒性效应

研究了在不同浓度镉(10～40mg/L)中暴露30d黑斑蛙(Rana nigromaculata)脏器组织的亚慢性毒性效应.结果表明,当镉暴露浓度>30mg/L时,黑斑蛙的肝脏指数显著减少.黑斑蛙肝脏、肾脏和心脏Na⁺-K⁺-ATPase活性随着Cd²⁺浓度的升高而降低,表现出明显的浓度-效应关系.在同一浓度(20mg/L)不同时间处理中,肝脏、肾脏组织Na⁺-K⁺-ATPase活性随处理时间的延长表现为先升高后下降的趋势.肝脏和肾脏Na⁺-K⁺-ATPase对Cd²⁺更为敏感.肝脏指数的减少和肝脏、肾脏、心脏组织Na⁺-K⁺-ATPase活性的变化在一定程度上反映了镉对黑斑蛙的损伤作用.

Subchronic toxic effects of cadmium on the viscera tissues of the frog Rana nigromaculata

The subchronic toxic effects of Rana nigromaculata viscera tissues exposed 30d in different Cd2+ concentrations (10~40mg/L) were studied adopting toxial experiment technique. At the exposure concentration >30mg/L, the hepatosomatic index (HSI) of Rana nigromaculata decreased markedly. The Na+-K+-ATPase activities in the liver, kidney and heart decreased with Cd2+ concentration increased, expressing obvious concentration-effect relationship. In the treatment of same concentration (20mg/L) and different time, the Na+-K+-ATPase activities in the liver and kidney tissues tended to raise first and then declined, and there two tissues showed more sensitive on Cd2+. The decrease of HSI and the change of Na+-K+-ATPase activities of liver, kidney and heart reflected at definite degree the damage action of cadmium on Rana nigromaculata.