| 用苯及其生物代谢物酚、醌处理大鼠各器官中DNA加合物的形成和分布 |
| |
| 引用本文： | 刘淑芬,蒋湘宁,徐晓白.用苯及其生物代谢物酚、醌处理大鼠各器官中DNA加合物的形成和分布[J].环境科学学报,1996,16(2):179-183. |
| |
| 作者姓名： | 刘淑芬 蒋湘宁 徐晓白 |
| |
| 作者单位： | 中国科学院生态环境中心 |
| |
| 摘 要： | 用苯及其在生物体内代谢物酚，醌处理大鼠，２４ｈ后取基肝、肾、肺、脾诸组织，用＾３２Ｐ后标记方法测４种器官中ＤＮＡ加合物含量。其结果是：在上述各器均发现有ＤＮＡ加合物的形成，４咱器官中总加合物量值对苯、酚、醌依次为９．１８－８９．１３、２０．８－２４３．８、５３．１－３０８．９加合物／１０＾８正常核酸，３种系列化合物对大鼠４种器官中ＤＮＡＬ中合物形成能力依次为醌〉酚〉苯。而大鼠中４种器官对同一化合物
|
| 关 键 词： | DNA加合物 ^32P后标记 苯 酚 醌 大鼠 |
| 收稿时间： | 1995/1/26 0:00:00 |
FORMATION AND DISTRIBUTION OF DNA ADDUCT IN ORGANS OF RAT TREATED WITH BENZENE,PHENOL, OR BENZOQUINONE |
| |
| Liu Shufen,Jiang Xiangning and Xu Xiaobai.FORMATION AND DISTRIBUTION OF DNA ADDUCT IN ORGANS OF RAT TREATED WITH BENZENE,PHENOL, OR BENZOQUINONE[J].Acta Scientiae Circumstantiae,1996,16(2):179-183. |
| |
| Authors: | Liu Shufen Jiang Xiangning and Xu Xiaobai |
| |
| Institution: | Research Center for Eco-Environmental Sciences, Chinese Academy of Scineces, Beijing 100085,Research Center for Eco-Environmental Sciences, Chinese Academy of Scineces, Beijing 100085 and Research Center for Eco-Environmental Sciences, Chinese Academy of Scineces, Beijing 100085 |
| |
| Abstract: | DNA adducts produced in various organs (liver, kidney, lung, and spleen) of SD rats induced either by Areolar and administrated by a single injection of benzene, phenol, or benzoquinone have been analyzed by nuclease P1-mediated 32P-postlabelling. The results showed that the RAL of DNA adduct were 9. 8-89. 13 (benzene), 20. 9243. 8 (phenol), 53. 1208. 9 (benzoquinone) adduct/108 normal nucleate. The relationship between extent of DNA adduct formation and genotoxicity of chemicals was benzoquinone>phenol> benzene. |
| |
| Keywords: | |
| 本文献已被 维普 等数据库收录！ |
| 点击此处可从《环境科学学报》浏览原始摘要信息 |
| 点击此处可从《环境科学学报》下载免费的PDF全文 |
|
