| 取代芳烃对酵母菌毒性的定量结构－活性相关研究 |
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| 引用本文： | 廖宜勇,周玳,刘征涛,韩朔睽,王连生.取代芳烃对酵母菌毒性的定量结构－活性相关研究[J].环境科学学报,1996,16(3):349-355. |
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| 作者姓名： | 廖宜勇 周玳 刘征涛 韩朔睽 王连生 |
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| 作者单位： | 南京大学环境科学与工程系 |
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| 摘 要： | 定量测定了苯胺类、苯甲酸类、卤代苯类、苯腈类、硝基苯类、苯酚类等６类化合物对酵母菌的生长抑制毒性，结果表明化合物的最小产生清晰抑菌圈浓度Ｃｍｉｚ与辛醇－水分配系数及一阶分子连接性价指数有如下关系：ｌｏｇ（１／Ｃｍｉｚ）＝０．３８ｌｏｇＫｏｗ＋０．３３＾１Ｘ＾ｖ－０．３８ ｒ＝０．９２ ｓ＝０．２２ ｎ＝７７。在上述６类取代苯类化合物中，它们与酵母菌的反应性大小有如下顺序：卤代苯类≈苯甲酸类〈苯胺类
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| 关 键 词： | 毒性评价 酵母菌 有机污染物 生物评价 |
| 收稿时间： | 1994/10/11 0:00:00 |
A QSARs STUDY ON THE TOXICITY OF SUBSTITUTED BENZENET YEAST SACCHAROMYCES CEREVISIAE |
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| Liao Yiyong,Zhou Dai,Liu Zhengtao,Han Shuokui and Wang Liansheng.A QSARs STUDY ON THE TOXICITY OF SUBSTITUTED BENZENET YEAST SACCHAROMYCES CEREVISIAE[J].Acta Scientiae Circumstantiae,1996,16(3):349-355. |
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| Authors: | Liao Yiyong Zhou Dai Liu Zhengtao Han Shuokui and Wang Liansheng |
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| Institution: | Department of Environmental Sciences & Engineering, Nanjing University, Nanjing 210093,Department of Environmental Sciences & Engineering, Nanjing University, Nanjing 210093,Department of Environmental Sciences & Engineering, Nanjing University, Nanjing 210093,Department of Environmental Sciences & Engineering, Nanjing University, Nanjing 210093 and Department of Environmental Sciences & Engineering, Nanjing University, Nanjing 210093 |
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| Abstract: | The toxicities of 78 substituted benzene to years Saccharomyces Cerevisiae were studied. A QSAR equation was derived to predict the minimum inhibition zone concentration (Cmiz):log(1/Cmiz)=0. 38logKow+0. 331Xv-0. 38r=0. 92s=0. 22n=77. The toxicities of the substituted groups on benzene decrease in following order based on FreeWilson analysis:-Br (0. 84)> -(0. 54)> -(0. 39)>- NO2 (0. 35)> -COOH (0. 19)=-OH (0. 17)= -CHO (0. 17)=-CN (0. 14)>-F (-0. 03)>-NH2 (-0. 08). The relationship between the toxicity and the molecular connectivity indices was also discussed. |
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| Keywords: | toxicity assessment QSARs yeast saccharomyces cerevisiae |
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