| 溴化1-十四烷基-3-甲基咪唑对小鼠的肝脏毒性及其作用机制 |
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| 引用本文： | 徐红梅,宣怡红,江云,任娜,丁运生,吕丹,张毅帆,李小雪,周剑,许凯兵.溴化1-十四烷基-3-甲基咪唑对小鼠的肝脏毒性及其作用机制[J].生态毒理学报,2013,8(5):791-798. |
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| 作者姓名： | 徐红梅 宣怡红 江云 任娜 丁运生 吕丹 张毅帆 李小雪 周剑 许凯兵 |
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| 作者单位： | 1. 合肥工业大学医学工程学院 制药工程系，合肥 230009
2. 合肥工业大学安徽省先进功能材料与设备重点实验室，合肥 230009;合肥工业大学医学工程学院 制药工程系，合肥 230009;合肥工业大学医学工程学院 制药工程系，合肥 230009;合肥工业大学化学工程学院，合肥 23000;1. 合肥工业大学安徽省先进功能材料与设备重点实验室，合肥 230009
2. 合肥工业大学化学工程学院，合肥 23000;合肥工业大学医学工程学院 制药工程系，合肥 230009;合肥工业大学医学工程学院 制药工程系，合肥 230009;合肥工业大学医学工程学院 制药工程系，合肥 230009;合肥工业大学医学工程学院 制药工程系，合肥 230009;合肥工业大学医学工程学院 制药工程系，合肥 230009 |
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| 基金项目： | 国家自然科学基金(50973025)；合肥工业大学大学生创新创业实验(2012CXCY475) |
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| 摘 要： | 研究离子液体溴化1-十四烷基-3-甲基咪唑盐(C14mim]Br)对小鼠的肝脏毒性及其作用机制。实验设立3个剂量的染毒组(1/16 LD50、1/8 LD50、1/4 LD50)和1个空白对照组，考察昆明种小鼠染毒14 d后，C14mim]Br对小鼠血清生化指标、肝脏抗氧化酶活性及脂质过氧化产物的影响，并观察肝脏组织的病理变化。与对照组相比，小鼠染毒后，血清中ALT、AST、DBIL和γ-GT明显升高；肝组织受到不同程度的损伤，HSI增大，蛋白质含量降低。当染毒剂量为1/4 LD50时，肝脏中SOD活性和GSH-Px活性显著降低，MDA的含量则明显增加。实验结果表明，C14mim]Br可损伤小鼠的肝脏功能，破坏机体的抗氧化防御系统，造成氧化损伤和脂质过氧化。
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| 关 键 词： | 离子液体 溴化1-十四烷基-3-甲基咪唑盐 肝毒性 小鼠 |
| 收稿时间： | 5/8/2013 12:00:00 AM |
| 修稿时间： | 2013/7/10 0:00:00 |
The Hepatotoxicity and Mechanism of Bromide 1-Tetradecyl-3-Methyl Imidazole to Mice |
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| Xu Hongmei,Xuan Yihong,Jiang Yun,Ren N,Ding Yunsheng,Lv Dan,Zhang Yifan,Li Xiaoxue,Zhou Jian and Xu Kaibing.The Hepatotoxicity and Mechanism of Bromide 1-Tetradecyl-3-Methyl Imidazole to Mice[J].Asian Journal of Ecotoxicology,2013,8(5):791-798. |
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| Authors: | Xu Hongmei Xuan Yihong Jiang Yun Ren N Ding Yunsheng Lv Dan Zhang Yifan Li Xiaoxue Zhou Jian and Xu Kaibing |
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| Institution: | 1. Department of Pharmaceutical Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009, China
2. Anhui Provincial Key Laboratory of Advanced Functional Materials and Devices, Hefei University of Technology, Hefei 230009, China;Department of Pharmaceutical Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009, China;Department of Pharmaceutical Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009, China;School of Chemical Engineering, Hefei University of Technology, Hefei 230009, China;1. Anhui Provincial Key Laboratory of Advanced Functional Materials and Devices, Hefei University of Technology, Hefei 230009, China
2. School of Chemical Engineering, Hefei University of Technology, Hefei 230009, China;Department of Pharmaceutical Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009, China;Department of Pharmaceutical Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009, China;Department of Pharmaceutical Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009, China;Department of Pharmaceutical Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009, China;Department of Pharmaceutical Engineering, School of Medical Engineering, Hefei University of Technology, Hefei 230009, China |
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| Abstract: | |
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| Keywords: | ionic liquids bromide 1-tetradecyl-3-methyl imidazole salt hepatotoxicity KM mouse |
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