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Association of serum levels of polychlorinated biphenyls with IL-8 mRNA expression in blood samples from asthmatic and non-asthmatic Japanese children
Authors:Tsuji Mayumi  Vogel Christoph F A  Koriyama Chihaya  Akiba Suminori  Katoh Takahiko  Kawamoto Toshihiro  Matsumura Fumio
Affiliation:a Department of Environmental Toxicology, University of California Davis, Davis, CA 95616, United States
b Department of Public Health, Graduate School of Medical Sciences, Kumamoto University. 1-1-1 Honjo, Kumamoto 860-8556, Japan
c Department of Environmental Health, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyusyu 807-8555, Japan
d Department of Epidemiology and Preventive Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
Abstract:

Background

One of the suggested health outcomes of PCB exposure is childhood asthma.

Objectives

This study was conducted to find health relevant biomarkers providing the molecular epidemiological evidence for the positive relationship between exposure to PCBs and childhood asthma.

Methods

Blood samples from fifteen asthmatic children as well as an equal number of non-asthmatic children (average 2 year old) were collected, and were analyzed for PCBs and their select marker expression by using qRT-PCR.

Results

Among biomarkers examined IL-8 expression was significantly correlated to serum levels of PCB #163 + 164 (P = 0.022), #170 (P = 0.046), #177 (P = 0.022), #178 (P = 0.022) and #180 + 193 (P = 0.046) in a dose-dependent manner, which was found only among asthmatic children. In contrast, COX-2 correlations to individual congener levels were recognized only among control subjects, not among asthmatic subjects.

Conclusion

Serum concentrations of PCB#163 + 164, #170, #177, #178 and #180 + 193 correlate significantly with IL-8 mRNA expressions among asthmatic children.
Keywords:Young children   PCBs   IL-8   Asthma   AHR
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