Dimethylcarbonate for eco-friendly methylation reactions |
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Authors: | Memoli S Selva M Tundo P |
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Institution: | Interuniversity, Consortium Chemistry for the Environment, Venice, Marghera, Italy. |
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Abstract: | Dimethylcarbonate (DMC), an environmentally friendly substitute for dimethylsulfate and methyl halides in methylation reactions, is a very selective reagent. Both under gas-liquid phase transfer catalysis (GL-PTC) and under batch conditions, with potassium carbonate as the catalyst, the reactions of DMC with methylene-active compounds (arylacetonitriles and arylacetoesters, aroxyacetonitriles and methyl aroxyacetates, benzylaryl- and alkylarylsulphones) produce monomethylated derivatives, with a selectivity not previously observed (i.e., >99%). The highly selective O-methylation of phenols and p-cresols by DMC is also attained by a new methodology using a continuous fed stirred tank reactor (CSTR) filled with a catalytic bed of polyethyleneglycol (PEG) and potassium carbonate. |
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