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Some pharmacokinetic aspects of PCDDs and PCDFs in mammals after administration of a fly ash extract from a municipal incinerator |
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| Authors: | Martin van den Berg Carola Heeremans Liesbeth Meerman Els Veenhoven Jikke van Wijnen Kees Olie Otto Hutzinger |
| Affiliation: | Laboratory of Environmental and Toxicological Chemistry University of Amsterdam, Nieuwe Achtergracht 166 1018 WV, Amsterdam, The Netherlands Chair of Ecological Chemistry and Geochemistry University of Bayreuth, Postfach 3008, D-8580, Bayreuth, Germany |
| Abstract: | Fly ash extracts were fed to male hamster (single dose), male rat (single dose and multiple dose), pregnant and lactating female rat (multiple dose). The retention of four isomers, 2,3,7,8-TCDD, 2,3,7,8-TCDF, 1,2,3,7,8-PnCDD and 2,3,4,7,8-PnCDF, was studied in the liver of the adults, foetuses and liver of the sucklings. Liver retention was structure dependent and different for both species. Transportation of the isomers via the mother milk was 50–100 times more effective than via the placenta. After a single intravenous dose of fly ash extract to male rats the elimination of these four isomers was studied in the liver, during a period of 10 days. Elimination rates for 2,3,7,8-TCDD, 1,2,3,7,8-PnCDD and 2,3,4,7,8-PnCDF were in the same range. Pharmacokinetic calculations were done on both tetra congeners, to obtain information about the validity of the published Ke values in the multiple dose experiments with male rats. For 2,3,7,8-TCDF the Ke value was applicable, but for 2,3,7,8-TCDD the validity of the Ke could not be determined. |
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