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Transfer-RNA,an early gene?
Authors:Manfred Eigen  Ruthild Winkler-Oswatitsch
Institution:1. Max-Planck-Institut für biophysikalische Chemie, D-3400, G?ttingen
Abstract:The theory of self-reproductive molecular systems involves the consequence that translation must have started from a selected distribution of RNA molecules, that comprised GC-rich sequences of a length < 100 nucleotides. This implies a joint function of messenger and adaptor, which both had to be recruited from the same mutant distribution. The reconstruction of tRNA precursors yields such a molecule showing some reverberation of a codon pattern GNC. These findings suggest that tRNA has been the earliest component of the translation machinery.
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