| U PLC- ESI- MS/MS法同时测定水中7种抗生素 |
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| 引用本文： | 张川,胡冠九,孙成.U PLC- ESI- MS/MS法同时测定水中7种抗生素[J].环境监测管理与技术,2009,21(3):37-40. |
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| 作者姓名： | 张川 胡冠九 孙成 |
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| 作者单位： | 1. 污染控制与资源化研究国家重点实验室,南京大学环境学院,江苏,南京,210093
2. 污染控制与资源化研究国家重点实验室,南京大学环境学院,江苏,南京,210093;江苏省环境监测中心,江苏,南京,210036 |
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| 基金项目： | 江苏省环境监测科研基金 |
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| 摘 要： | 采用超高效液相色谱-电喷雾二级质谱联用技术同时测定水中7种抗生素,优化了试验条件.磺胺甲恶唑、诺氟沙星、环丙沙星、氧氟沙星、四环素在1.00 ng/L～1000 ng/L范围内线性良好,定量下限为1 ng/L,土霉素、金霉素在10.0 ng/L-2 000 ng/L范围内线性良好,定量下限为10 ng/L,去离子水和地表水样加标回收率为72.1%-112%,RSD为0.6%～9.2%.
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| 关 键 词： | 抗生素 超高效液相色谱 电喷雾 二级质谱 水质 |
Simultaneous Analysisof 7 Antibioticsin Water by Ultra Performance Liquid Chromatography-Electrospray Ionization-Tandem MassSpectrometry |
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| ZHANG Chuan,HU Guan-jiu,SUN Cheng.Simultaneous Analysisof 7 Antibioticsin Water by Ultra Performance Liquid Chromatography-Electrospray Ionization-Tandem MassSpectrometry[J].The Administration and Technique of Environmental Monitoring,2009,21(3):37-40. |
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| Authors: | ZHANG Chuan HU Guan-jiu SUN Cheng |
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| Abstract: | An ultra performance liquid chromatography -electrospray ionization-tandem mass spectrometry (UPLC 2 ESI 2 MS/MS) analysis method wasestablished forthe simultaneousanalysisof 7 antibioticsin water. The experimentalconditionswereoptimizedto producefollowingresults: goodlinearityofsulfamethoxazole, norfloxacin, ciprofloxacin, ofloxacin and tetracyclinein the range from 1.00 ng/L to 1 000 ng/L and thelimitsof quantification(LOQ) 1 ng/L, the good linearity ofterramycin and aureomycin in the range from 10.0 ng/L to 2 000 ng/L and the LOQ 10 ng/L,the recoveriesofdeionized waterand surface waterfrom 72.1% to 112% , and the RSD from 0.6% to 9.2%. |
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| Keywords: | Antibiotics Ultra- HPLC Electrospray Tandem massspectrometry Waterquality |
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