超高效液相色谱三重四极杆质谱联用法测定水中的丙烯酰胺

将含有丙烯酰胺的水样过滤后加入甲酸酸化,然后直接进样,使用超高效液相色谱三重四极杆质谱联用法测定,通过选择离子反应监测,可实现定性和外标法定量分析.该方法测定生活饮用水及其水源水中丙烯酰胺的最低检测浓度为0.15 g/L,对实际样品的加标回收率在92％ ～ 123％,该方法绿色环保、简单方便,且具有较高的灵敏度和较低的检出限.

Determination of Acrylamide in Drinking Water by Ultra Performance Liquid Chromatography Coupled with Triple Quadrupole Mass Spectrometry

Water samples containing acrylamide were filtered and acidized by formic acid, then directly injected and finally detected by ultra performance liquid chromatography coupled with triple quadrupole mass spectrometry. Qualitative and quantitative analysis by external standard were achieved by electrospray ionization in positive mode using multiple reaction monitoring. The limit of determination for acrylamide in drinking water was 0.15mg/L. The average recovery rate of real samples was in the range of 92%~123%. This method was environment friendly, simple and sensitive.