高分辨质谱在环境科学领域应用综述

探究复杂环境介质中有机污染物分析检测新方法，建立复杂环境介质中可疑和非目标化合物的快速筛选及确证方案，已成为环境科学领域的研究热点。高分辨质谱仪（HR-MS）具有质量范围宽、扫描速度快、灵敏度高等优点，使其在环境科学领域得到广泛应用。综述了混合高分辨率质谱（Q-TOF/Q Orbitrap）等HR MS技术的特点和工作原理，基于目标化合物分析、可疑化合物分析以及非目标化合物分析这3类研究策略，阐述了HR-MS在环境研究、药品监管及生物代谢物研究等领域的应用现状，进而分析了现阶段HR MS在环境科学领域中的应用局限性和发展前景。

Application of High resolution Mass Spectrometry in the Field of Environmental Science: A Critical Review

In recent years, it has become a research hotspot in the field of environmental science to explore new methods for the analysis and detection of organic pollutants in complex environmental media and to establish a rapid screening and confirmation scheme for identifying suspicious and non target compounds in complex environmental matrices. High resolution mass spectrometer (HR-MS) has been widely used in the field of environmental science because of its wider mass range, faster scanning speed and higher sensitivity. This paper summarizes the technical characteristics and working principles of Q-TOF and Q-Orbitrap. Based on the three research strategies of target compound analysis, suspicious compound analysis and non target compound analysis, this paper expounds the application status of HR-MS in the fields of environmental research, drug supervision and metabolite research, and then analyzes the application limitations and development prospects of HR MS in the field of environmental science at this stage.