环境糖皮质激素受体干扰物的研究进展

综述了糖皮质激素受体干扰物的作用机制和生态效应,列举了多种活性筛选方法,并根据性质对干扰物进行了种类的划分。在当前环境糖皮质激素受体干扰物研究的基础上,指出了作用机制的研究不全面、个体生物筛选方法匮乏、缺少可信的活性模拟预测技术等问题,并提出了应借助模式生物完善作用机制研究,在此基础上建立稳定、高通量的个体生物活性筛选方法和动力学过程模拟替代技术用以活性预测等发展方向。

Study Progress of Environmental Contaminants with Glucocorticoid Receptor (GR) -dis-rupting Activities

The mechanism of action and ecological effects of GR-disrupting chemicals were reviewed in this paper. Moreover, differ-ent methods for GR-activity screening were summarized and disrupting chemicals were classified. On the basis of current studies on GR-disrupting chemicals, knowledge gaps were identified, which include the further elucidation of mechanism, the development of in vivo screening methods and the prediction of GR-disrupting activities. According to these, there is a need to obtain more informa-tion on model organisms. Furthermore, establishing the stable high throughput in vivo screening methods and optimizing computa-tional simulation based on molecular dynamic process to generate reliable data for minimum cost should be taken into account in the future research.